Highlight of New Phosphodiesterase 10A Inhibitors Using Molecular Docking
نویسندگان
چکیده
منابع مشابه
Molecular docking of competitive phosphodiesterase inhibitors.
Mammalian phosphodiesterases types 3 and 4 (PDE3 and PDE4) hydrolyze cAMP and are essential for the regulation of this intracellular second messenger. These enzymes share structural and biochemical similarities, but each can be distinguished by its sensitivity to isoenzyme-specific, substrate-competitive inhibitors. We present a model configuration for the PDE4 substrate (cAMP) and a PDE4-speci...
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ژورنال
عنوان ژورنال: Current Research in Bioinformatics
سال: 2019
ISSN: 2524-2172
DOI: 10.3844/ajbsp.2019.34.37